In a recent study published in Medical Sciences Forum, Portuguese researchers explored the anti-cancer potential of sRNA from Boletus edulis (Porcini) and Agaricus bisporus (Portobello) mushrooms. The study also assessed whether these mushrooms' microRNAs might possess anti-cancer properties.
Experiments conducted on normal and cancer cell lines showed that while all mushroom sRNAs exhibited anti-cancer properties, their relative activities varied significantly. This suggests that anti-cancer sRNAs are enriched in specific sequences. These findings underscore the potential of mushrooms as sources of biomolecules with anti-cancer potential and emphasize the need for further research into commonly available fruits, vegetables, and fungi.
The study also compared sRNA fractions from Cantharellus cibarius (CCI), Boletus edulis (BED), and Agaricus bisporus (ABI), commonly known as Portobello. The results revealed that ABI's sRNA was capable of suppressing cancer cell viability, while BEDB and CCI3 showed high anti-cancer efficacy at low dosages.
Source: news-medical.net